^{Stem Cell and Regenerative Medicine}

Biography

Biography: Yuval Rinkevich

Abstract

All mammals and humans undergo metamorphosis in response to injury, from Regeneration To Scarring (RTS). Here we follow two functionally diverged fibroblastic lineages (ENFs & EPFs) and document their lineage successions during backskin development that coincides with RTS. We show that ENFs are dermal sculptures that develop and regenerate native architectures during fetal life, and that their lineage decline over time imposes a dermal tissue absent of such events. We show that EPFs are scar producers even at fetal stages, wherein their numbers are below a threshold needed to generate macroscopic scars, but that their dynamics predicts scar emergence. We show that clonal advantages to EPFs rather than programed cell lineage death, most likely are primary succession mechanisms, and that RTS can be partly circumvented by transplantations of fetal ENFs or decellularised fetal dermis. Our findings provide a mechanism for regenerative decline in mammals, carry clinical implications by suggesting that human dermal regeneration could be reached by coxing or transplanting ENFs alone, and provide a model for comparative regeneration studies between taxon groups.