Biography
Biography: Huanhuan Joyce Chen
Abstract
Current cancer research hinges on developing models that accurately recapitulate cancer disease phenotypes. Though animal models are very useful tools, the major limitation stems from species variation that animal models can be considerable different to human cancers and fail to faithfully recapitulate human conditions. To address this issue, we engineered an ex vivo colon cancer models by recellularization of human native matrix with human colonic stem cells derived cell resources. We followed to demonstrate the significance of the organotypic human-originated model in studying cancer biology by combining transposon-based mutagenesis. Another problem rises from the availability of tissue-specific cell types representative of clinical disease features, especially in the lung cancer types with the scarcity of primary tumors for generation of cell lines. Here, I will also describe my current efforts to synthesize cellular engineering, single-cell methods with human pluripotent stem cell technology for lung cancer modeling.