Stem Cell and Regenerative Medicine

Here, we reported three patient cases in which they were seriously injured by accidents. Among them, two of them were injured by car accidents and the third patient was injured by falling down from Chinese house roof approximate 3 meter high, respectively. The common symptoms of them are head and chest vertebral injury, coma and incontinence of feces and pee, numbness of lower limb and disabled or restricted movement and so forth. After regular treatments at hospitals for different periods, all of them only obtained minor function recoveries. After subsequent 2 or 3 courses of treatment with neural stem cells, significant physical function improvements were successfully achieved. These functional recoveries included feeling strong waist, sitting up freely but cannot stand, perceiving feces and pee but cannot control, the left leg can move horizontally but cannot lift up, the right leg can lift up but cannot resist the resistance, higher double lower limb muscle tensions, having feeling obstacle under xiphoid process and the double arms can move freely, etc. More importantly, after stem

cell transplantation therapy, one of them, could crawl and even could walk with the help of walking aid. These preliminary clinical trials vividly demonstrated that the feasibility of stem cell therapy for the patients with serious brain and spinal cord injuries and provided pioneer evidences for further clinical trials with various stem cells to treat different human diseases.