Prabhu Mishra
CEO, Co-Founder- Stemgenn Therapeutics and secretary general-stem cell society, India
Title: Role of Autologous Stem cells in Infertility
Biography
Biography: Prabhu Mishra
Abstract
Stem cells are undifferentiated cells that are present in the embryonic, fetal and adult stages of life and give rise to differentiated cells that make up the building blocks of tissue and organs. Medical definition of infertility is failure to conceive after > 12 months of unprotected intercourse reported by 1 in 6 couples. The major characteristics of stem cells are self-renewable, plasticity and potency. Peripheral blood derived concentrate contain growth factors like fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β) due to which stem cells considered as potentially new therapeutic agents for the treatment of infertility. Commonly stem cells are of two types: embryonic stem cells and adult stem cells (Hematopoetic stem cells and Mesenchymal stem cells). Another type is induced pluripotent stem cell which is generated by reprogramming of somatic cells. During past few years a considerable progress in the derivation of male germ cells from pluripotent stem cells has been made. Platelet rich plasma (PRP) has shown a great success in treating thin endometrium which is a cause of failed IVF in infertile women. PRP secrete growth factors and increase the thickness of endometrium and increase the quality of blood flow. Bone Marrow concentrate may have potential role in treating Asherman Syndrome, Poor Ovarian Reserve, Oligospermia and non-obstructive Azoospermia.